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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: KIF11 All Species: 36.67
Human Site: T346 Identified Species: 50.42
UniProt: P52732 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52732 NP_004514.2 1056 119159 T346 A S L N L E E T L S T L E Y A
Chimpanzee Pan troglodytes XP_507923 1056 119132 T346 A S L N L E E T L S T L E Y A
Rhesus Macaque Macaca mulatta XP_001087644 853 96218 V194 D P R N K R G V I I K G L E E
Dog Lupus familis XP_534964 1334 149091 T628 A S L N L E E T L S T L E Y A
Cat Felis silvestris
Mouse Mus musculus Q6P9P6 1052 118008 T345 A S F N L E E T L S T L E Y A
Rat Rattus norvegicus O55165 796 89797 Q137 H I S R S Q N Q Q Y L V R A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90640 1225 138905 T325 A D S N L E E T L N T L R Y A
Frog Xenopus laevis P28025 1060 119314 T339 A S I N L E E T V S T L D Y A
Zebra Danio Brachydanio rerio NP_775368 955 106984 R296 Q S L L T L G R V I K A L V E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P46863 1066 121145 T343 G H K D I E E T L S T L E Y A
Honey Bee Apis mellifera XP_623508 706 80766 I47 Q S N K E V I I R E R P H D K
Nematode Worm Caenorhab. elegans P46873 699 78760 A40 V G Q V N L N A P D G A A K D
Sea Urchin Strong. purpuratus P46872 699 78679 G40 V K M D E M R G T V Q V T N P
Poplar Tree Populus trichocarpa XP_002314206 1066 119757 T371 S I Q S L E E T L S T L D Y A
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P82266 1056 119250 T346 A V H C L E E T L S T L D Y A
Baker's Yeast Sacchar. cerevisiae P28742 1111 125776 T397 A K I S M E E T A S T L E Y A
Red Bread Mold Neurospora crassa P48467 928 102392 I269 L S A L G M V I N A L T D G K
Conservation
Percent
Protein Identity: 100 99.8 77.5 69.3 N.A. 79.7 23.3 N.A. N.A. 25.3 56.2 47.7 N.A. 33.5 37.1 27.4 29.2
Protein Similarity: 100 99.9 79 73.8 N.A. 89 40.4 N.A. N.A. 43.5 72.7 63.9 N.A. 55.4 52 42.5 42.8
P-Site Identity: 100 100 6.6 100 N.A. 93.3 0 N.A. N.A. 73.3 80 13.3 N.A. 66.6 6.6 0 0
P-Site Similarity: 100 100 13.3 100 N.A. 93.3 20 N.A. N.A. 80 100 20 N.A. 80 6.6 0 20
Percent
Protein Identity: 32.9 N.A. N.A. 31.9 27.2 27.5
Protein Similarity: 52.3 N.A. N.A. 51.5 48.6 45.5
P-Site Identity: 66.6 N.A. N.A. 73.3 66.6 6.6
P-Site Similarity: 86.6 N.A. N.A. 80 86.6 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 48 0 6 0 0 0 0 6 6 6 0 12 6 6 59 % A
% Cys: 0 0 0 6 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 6 6 0 12 0 0 0 0 0 6 0 0 24 6 6 % D
% Glu: 0 0 0 0 12 59 59 0 0 6 0 0 36 6 12 % E
% Phe: 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 6 6 0 0 6 0 12 6 0 0 6 6 0 6 0 % G
% His: 6 6 6 0 0 0 0 0 0 0 0 0 6 0 0 % H
% Ile: 0 12 12 0 6 0 6 12 6 12 0 0 0 0 0 % I
% Lys: 0 12 6 6 6 0 0 0 0 0 12 0 0 6 12 % K
% Leu: 6 0 24 12 48 12 0 0 48 0 12 59 12 0 0 % L
% Met: 0 0 6 0 6 12 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 6 42 6 0 12 0 6 6 0 0 0 6 0 % N
% Pro: 0 6 0 0 0 0 0 0 6 0 0 6 0 0 6 % P
% Gln: 12 0 12 0 0 6 0 6 6 0 6 0 0 0 0 % Q
% Arg: 0 0 6 6 0 6 6 6 6 0 6 0 12 0 0 % R
% Ser: 6 48 12 12 6 0 0 0 0 53 0 0 0 0 6 % S
% Thr: 0 0 0 0 6 0 0 59 6 0 59 6 6 0 0 % T
% Val: 12 6 0 6 0 6 6 6 12 6 0 12 0 6 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 6 0 0 0 59 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _